Related titles << BACK


Self-Assembling Complexes for Gene Delivery
From Laboratory to Clinical Trial

Edited by A. KABANOV, University of Nebraska Medical Center, USA, L.W. SEYMOUR, CRC Institute for Cancer Studies, University of Birmingham, UK and P. FELGNER, Viral Inc., San Diego, USA

This timely volume provides a clear, comprehensive overview of the major chemical, biological and clinical aspects of self-assembling complexes for gene delivery. It explains the rationale behind synthetic self-assembling systems, with individual sections focusing upon the major chemical, biological and clinical aspects of self-assembling complexes.

Contents:

  • PRINCIPLES OF SELF-ASSEMBLY: Polymorphism of lipids, nucleic acids, and their interactions
  • Structure of polycation – DNA complexes and theories of compaction
  • Self-assembly of bacteriophage NATURAL MECHANISMS FOR GENE DELIVERY TO CELLS: Endocytosis: an overview
  • Delivery of animal virus DNA into the nucleus NOVEL SYSTEMS USING CATIONIC LIPOSOMES: Novel supramolecular assemblies for gene delivery
  • Taking lipospermines and polyethylenimine from in vitro to in vivo
  • Terplex system for delivery of DNA and oligonucleotides POLYELECTROLYTE DNA COMPLEXES: Characterization of polycation complexes with DNA
  • Interpolyelectrolyte complexes for gene delivery: polymer aspects of transfection activity
  • Cationic block copolymers as self-assembling vectors for gene delivery
  • Gene transfer using Starburst dendrimers
  • Cellular internalization and fate of polycation – DNA complexes SYSTEMATIC BIODISTRIBUTION OF DRUG DELIVERY SYSTEMS: In vitro and in vivo availability of liposomes
  • Pharmacokinetics of macromolecules and synthetic gene delivery systems TARGETING OF CONJUGATES FOR GENE DELIVERY: Polylysine-conjugate based DNA delivery
  • Hepatocyte targeting of polylysine conjugates in vivo
  • Peptide-mediated gene delivery
  • Peptides and fusion proteins as modular DNA carriers NEW APPROACHES TO GENE DELIVERY: Semi-synthetic systems for gene delivery
  • Sustained-release gene delivery systems: principles and perspectives CLINICAL EVALUATION: Cystic fibrosis clinical trials
  • Cancer gene therapy using nonviral vectors: preclinical and clinical observations

0471 97269 X460ppApril 1998Hardback

Home | Feedback | About Wiley

© John Wiley & Sons Ltd, 1999.   
(Best viewed with Navigator 4 or MSIE 4 and 16bit colour)

Visit Wiley Journals Online