Edited by Jean-Michel Metry, AARDEX Ltd., Zug, Switzerland and Urs A. Meyer, University of Basel, Switzerland

A patient's non-compliance with drug regimens can render drugs ineffective. This not only causes problems for the patient, but also large costs for health services. Despite a renewed interest in the subject over the past few years, there is still a dearth of new ideas and perspectives. An authoritative and timely volume, this invaluable work comprehensively covers all issues of drug regimen compliance. Divided into three main sections - Clinical Trials, Patient Management, and Future Aspects - it provides a controversial topic of debate and interest. An excellent source of information, it is ideal for people working in clinical drug development, clinical pharmacology, drug information and pharmaceutical marketing.

Contents

• Measuring Compliance in Clinical Trials and Ambulatory Care
• Design and Analysis of Clinical Trials of Compliance
• Achieving and Assessing Therapeutic Coverage
• Modeling and Simulation of Variable Drug Exposure
• Promises for a Measurement Breakthrough
• The Place of Microelectronic Systems in Measuring Compliance
• Non-compliance and Clinical Trials
• Regulatory Perspectives
• Regulatory Issues
• Pharmacoeconomics of Variable Compliance
• The Role of Compliance in Suboptimal Compliance
• The Role of Compliance in Clinical Care
• Behavioural Strategies for Long-term Survival of Organ Transplant Recipients
• Commercial Implications of Reliable Patient Information