Stephen Senn, University College, London, UK

Cross-Over Trials in Clinical Research provides a practical and comprehensive introduction to this important tool within the pharmaceutical industry. Aimed at guiding practitioners in the methods of using cross-over designs efficiently, it presents insight into how such trails may be designed and analysed. Key features include:

• A focus on the two-period AB/BA design, including the most up-to-date developments
• Important aspects of special design such as graphical and tabular presentation of trials, robust approaches to analysis, and practical issues in planning
• Direct relevance to drug development with an approach rooted firmly in biology and pharmacokinetics rather than stressing the mathematical aspects
• Detailed discussion and illustration of all techiques included together with many practical examples drawn from the author's wide-ranging experience

Contents

• Introduction
• Some Basic Considerations Concerning Estimation in Clinical Trials
• The AB/BA Design with Normal Data
• Other Outcomes and the AB/BA Design
• Normal Data from Designs with Three or More Treatments
• Other Outcomes from Designs with Three or More Treatments
• Some Special Designs
• Graphical and Tabular Presentation of Cross-Over Trials
• Various Design Issues
• Mathematical Approaches to Carry-Over
• References
• Index