Edited by B. Strom, University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics, USA

Already a highly successful and reputable book, the 3rd Edition includes new material and significant updates to reflect recent developments in the field. The book examines all areas of ‘pharmacoepidemiology’, the discipline that applies the methods of epidemiology to clinical pharmacology. It looks at the effects, safety and use of drugs in defined populations.

Maintaining its well-established reputation with the same popular layout and easy-to-read style, Strom presents the information clearly and concisely. New areas that have been added include:

• Prescription event monitoring
• General practice research database
• Bioethical issues
• Drug utilisation review

Reviews from the Second Edition:

"This is quite a superb book … well laid out and written in a style which makes the reading enjoyable."

"The book is essential reading for anyone interested in pharmacoepidemiology."

"…the book is an excellent textbook, and a comprehensive reference which belongs in the library of every pharmaceutical manufacturer and regulator. "

Partial Contents

• What is Pharmacoepidemiology?
• Study Designs for Pharmacoepidemiology
• Sample Size Considerations for Pharmacoepidemiology Relevant to Pharmacoepidemiology Studies
• Basic Principles of Clinical Pharmacology Relevant to Pharmacoepidemiology Studies
• When Should One Perform Pharmacoepidemiology Studies?
• A Public Health Perspective from Academia
• A View from Industry
• A View from a Regulatory Agency
• A View from a US Courtroom
• The Spontaneous Reporting System in the United States
• Spontaneous Reporting Systems Outside the United States – Principles and Pitfalls
• Intensive Hospital-Based Cohort Studies
• Case-Control Surveillance
• Prescription Event Monitoring
• Group Health Cooperative of Puget Sound
• Kaiser Permanente Medical Care Programs
• Harvard Pilgrim Health Care
• United Health Group
• Medical Databases
• Heath Databases in Saskatchewan
• Automated Record Linkage in the Netherlands
• The Tayside Medicines Monitoring Unit (MEMO)
• General Practice Research Database
• Other Approaches to Pharmacoepidemiologic Studies
• Choosing Among the Available Approaches for Pharmacoepidemiologic Studies
• Bioethical Issues in Pharmacoepidemiology
• Impact of Pharmacoepidemiology and on Drug Policy and Vice Versa
• Pre-marketing Applications of Pharmacoepidemiology
• Studies of Drug Utilisation
• Evaluating and Improving Physician Prescribing
• Drug Utilization Review Programs
• Determining Causation from Case Reports
• Use of Randomized Clinical Trials for Pharmacoepidemiology Studies
• The Use of Pharmacoepidemiology to Study Beneficial Drug Effects
• Pharmacoeconomics: Economic Evaluation of Pharmaceutics
• The Future of Pharmacoepidemiology