John Whitehead, University of Reading, UK

Widely recognised as an authoritative text for medical statisticians, The Design and Analysis of Sequential Clinical Trials has now been updated to include recent advances in the field.

Emphasis is placed on the triangular test and other procedures based on straight line stopping boundaries. These methods allow for frequent or occasional interim analyses and permit the analysis of a wide variety of patient responses.

Primary features of this new edition include:

• A wide repertoire of sequential and group sequential designs
• Methods for valid analysis after a sequential trial
• Allowance for potentially confounding prognostic factors
• Detailed examples of recent implementations of sequential methods in clinical research

Contents

• Clinical Trials
• Allocating Patients to Treatments
• Measurement of Treatment Difference
• The Design of a Sequential Trial Using the Boundaries Approach
• The Analysis of a Sequential Trial
• Alternative Approaches to the Design and Analysis of Sequential Clinical Trials
• Prognostic Factors
• The Comparison of More than Two Treatments
• Implementation of Sequential Methods: Some Examples
• References
• Appendix
• Index