Combinatorial Chemistry

Synthesis, Analysis and Screening

G. Jung

This is an indispensable information source on combinatorial chemistry covering a broad range of synthetic methods of outstanding importance for industrial processes and including many practical tips and tricks.

Combinatorial chemistry is proven as a time and resource saving synthetic method, especially in the search for new drugs. But the last few years have also seen the development and introduction of a number of new and improved approaches to combinatorial sciences.

This book covers the latest developments and discusses a broad range of synthetic methods from solid-phase to solution-phase synthesis, and from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented as well as practical information of value to anyone working in organic synthesis, catalysis, biochemistry and biotechnology, pharmaceutical and clinical chemistry, material sciences and analytical chemistry.

Full table of Contents

• Combinatorial Chemistry
• Survey of Solid-Phase Organic Reactions
• Solution-Phase Combinatorial Chemistry
• Combinatorial Chemistry of Multicomponent Reactions
• Solid-Phase Anchors in Organic Chemistry
• The Use of Templates in Combinatorial Chemistry for the Solid Phase Synthesis of Multiple Core Structure Libraries
• Combinatorial Synthetic Oligomers
• Glycopeptide and Oligosaccharide Libraries
• RNA and DNA Aptamers
• Combinatorial Approaches to Molecular Receptors for Chemosensors
• Peptide Libraries in T-Cell-Mediated Immune Response
• Combinatorial Biosynthesis of Microbial Metabolites
• Design and Diversity Analysis of Compound Libraries for Lead Discovery
• How to Scale-up While Scaling Down: EVOscreen tm, a Miniaturized Ultra High Throughput Screening System
• High Throughput Experimentation in Catalysis
• FT-Infrared Spectroscopy and IR-Microscopy for On Bead Analysis of Compound Libraries
• Mass Spectrometric Analysis of Combinatorially Generated Compounds and Libraries
• High Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On-Bead Analysis of Solid-Phase Synthesis
• Automated Combinatorial Chemistry
• Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) for Analysis of Compound Libraries